About Author
Kodle D1,Sharma D2,Gupta D3,
1 P. G. Scholar, Department of Dravyaguna, PT khushilal sharma ayurveda college and institute bhopal, MP
2 Asst professor, Department of kayachikitsa, PT khushilal sharma ayurveda college and institute bhopal, MP
3 P G SCHOLAR, Department of Ayurveda samhita and sidhhant., PT khushilal sharma ayurveda college and institute bhopal, MP
Correspondence Address
Dr PALLAVI KODLE
PT khushilal sharma govt ayurved college bhopal mp
Contact No. : 6261678489, Email : kushpawar2608@gmail.com
Date of Acceptance : 29 Mar 2025
Date of Publication : 30 Mar 2025
Article ID : SD-IJAY_129
How to cite this article : http://doi.org/10.55552/SDNJAY.2025.3107
Abstract
The Indian native plant Nothapodytes nimmoniana demonstrates nature's remarkable capacity to produce large amounts of camptothecin (CPT), a potent compound that is helpful in the treatment of cancer. Modern cancer treatments rely heavily on CPT and its derivatives, such as topotecan and irinotecan. The FDA and national health agencies throughout the world have approved CPT and its variants for the treatment of various cancers. This plant has antibacterial, antioxidant, anti-inflammatory, anthelmintic, and antimalarial properties in addition to its ability to combat cancer. This demonstrates its wide range of possible medical applications. But there is a chance that this priceless plant will go extinct. The primary cause of overharvesting is the increased demand for CPT, which is difficult to produce in a lab. Because CPT is difficult and costly to generate artificially because of its complicated form, we must obtain it from the plant, which puts further strain on harvesting. Numerous compounds have been discovered in N. nimmoniana via studies:
CPT, or camptothecin: This essential material is present in the roots, bark, wood, and leaves. It has been demonstrated that this substance inhibits the proliferation of cancer cells, such as those seen in cervical cancer (HeLa), Dalton's Asiatic lymphoma, and breast cancer (MDA-MB-231). Other substances: The plant's therapeutic qualities are also influenced by a wide range of other substances, including tannins, flavonoids, carbohydrates, glycosides, proteins, lipids, phenolic compounds, saponins, steroids, terpenoids, and coumarins. It's crucial to keep in mind that although CPT and similar medications are incredibly beneficial, they can also have negative side effects.
Strong conservation measures and sustainable harvesting methods are necessary for N. nimmoniana, a significant medicinal resource that is in danger of going extinct, to remain available for use in medicine in the future.
KEY WORDS:- Nothapodytes nimmoniana, camptothecin, anticancer, medicinal plants.